Trial Details

Trial status:

Active (recruiting)

Recruitment start date:

30/10/2019

Funder:

BCRT: the Bone Cancer Research Trust

Sponsor:

UCL

Chief Investigator:

Prof Sandra Strauss

Recruitment target:

300-350

EudraCT number:

n/a

Contact details:

ctc.iconic@ucl.ac.uk

Note: For enquiries only. DO NOT use for clinical referrals.

Lay summary:

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ICONIC

Improving outcomes through Collaboration in OsteosarComa

Description

Design: Prospective observational cohort study.

Treatment:

No treatments are specified in ICONIC. Patients should be treated according to national guidelines including UK guidelines for the management of bone sarcomas and applicable current and future NICE guidance.

Key inclusion/exclusion criteria:

· New histological diagnosis of osteosarcoma or in the absence of osteoid seen on biopsy, pathology and imaging supportive of a diagnosis of osteosarcoma. (It is well recognised that some patients may present with features suggestive of osteosarcoma (under 40 years, radiological abnormality compatible) but in whom no osteoid is detected in needle biopsy. Although categorised as spindle cell tumour of bone,such patients are usually treated in an identical approach to osteosarcoma. A definite diagnosis of osteosarcoma is then often possible after surgery when the entire resection specimen is available.)

· Written informed consent of patient and/or parent/legal guardian

· Diagnosis more than four months prior to registration

Duration of recruitment: No treatment is prescribed for this trial, but patients will be followed up for up to four years after registration.

Aim

To improve treatment and outcomes for patients with osteosarcoma (OS) by establishing a clinically annotated cohort of newly diagnosed patients with OS with longitudinal collection of biospecimens.

Contact the trial team

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View trial documents

Trial protocols

Trial protocols must not be applied to patients treated outside trials. UCL CTC can only ensure that approved trial investigators are provided with amendments to protocols.

Name	Version	Current vers	Release date
Current protocol	5	Current	03/10/2024
Current protocol summary	5	Current	03/10/2024
Guide Download Extract Docs from UCL CTC Website	1	Current	03/10/2024

Trial documents

Name	Type	Version	Current vers	Release date
0.1 Trial management	Other	1	Current	03/10/2024
0.2 Protocol	Other	1	Current	03/10/2024
0.3 Patient information Current	Other	1	Current	03/10/2024
0.3 Patient information Superseded (1)	Other	1	Current	03/10/2024
0.3 Patient information Superseded (2)	Other	1	Current	03/10/2024
0.4 Ethics & Regulatory Approvals (1)	Other	1	Current	03/10/2024
0.4 Ethics & Regulatory Approvals (2)	Other	1	Current	03/10/2024
0.4 Ethics & Regulatory Approvals (3)	Other	1	Current	03/10/2024
0.4 Ethics & Regulatory Approvals (4)	Other	1	Current	03/10/2024
0.6 Site and Staff Information	Other	1	Current	03/10/2024
0.7 Patient Screening	Other	1	Current	03/10/2024
0.8 Laboratory Current	Other	1	Current	03/10/2024
0.8 Laboratory Superseded	Other	1	Current	03/10/2024
0.9 Data Management	Other	1	Current	03/10/2024
0.9 Data Management Chemo	Other	1	Current	03/10/2024
0.9 Data Management Surgery	Other	1	Current	03/10/2024

Cancer Research UK & UCL Cancer Trials Centre
University College London
90 Tottenham Court Road
London
W1T 4TJ

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Email:
ctc.enquiries@ucl.ac.uk
Telephone:
+44 (0)20 7679 9898 (General CTC Enquiries)
Fax:
020 7679 9899

CTC staff

University College London, Gower Street, London, WC1E 6BT +44 (0)20 7679 2000