Advanced
Trials portfolio
ALLCAR19
Immunotherapy for high risk/relapsed CD19+ Acute Lymphoblastic Leukaemia using CAR T-cells to target CD19
ALLCAR19 is a multi-site, non-randomised phase I trial in adults with high risk or refractory CD19+ B-cell Acute Lymphoblastic Leukaemia. The Advanced Therapy Investigational Medicinal Product (ATIMP) [...]
Area: Advanced therapies
Phase: Phase I
Status: Active (recruiting)
CARD
CAR19 Donor Lymphocytes for relapsed CD19+ malignancies following allogeneic transplantation
CARD is a single centre, single arm intra-patient dose-escalation phase I study in adults with relapsed CD19+ malignancies following allogeneic stem cell transplantation. The Advanced Therapies Invest [...]
Area: Advanced therapies
Phase: Phase I
Status: In follow-up (non-recruiting)
CARMIGO
Chimeric Antigen Receptor (CAR)-T cells to target GD2 for Diffuse Midline Glioma (DMG)
A single centre, open label, phase 1 trial using the continual reassessment method (CRM) to evaluate the safety and optimal biologic dose of an Advanced Therapy Investigational Medicinal Product (ATIM [...]
Area: Advanced therapies
Phase: Phase I
Status: Active (recruiting)
CAROUSEL
Immunotherapy using CAR T-cells to target CD19 for relapsed/refractory CD19+ Primary CNS Lymphoma
A single centre, non-randomised, open label phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in patients 16 years and above with relapsed/refractory CD19+ Primar [...]
Area: Advanced therapies
Phase: Phase I
Status: In follow-up (non-recruiting)
CARPALL
Immunotherapy with CD19/22 CAR redirected T-cells for high risk/relapsed paediatric CD19+ and / or CD22+ acute lymphoblastic leukaemia and other haematological malignancies
A multi-centre, non-randomised, open label phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and young adults with high risk, relapsed CD19+ and/or CD [...]
Area: Advanced therapies
Phase: Phase I
Status: In follow-up (non-recruiting)
CARPERS
Determining the mechanisms of loss of CAR-T cell persistence
CARPERS is an observational study aiming to analyse CAR-T cell persistence over time. It will be offered to patients with CD19-positive acute lymphoblastic leukaemia who will receive the commercially [...]
Area: Advanced therapies
Phase: Observational trials
Status: In set-up (funded)
CD-19TPALL
Immunotherapy with CD19? gene modified EBV-specific CTLs after stem cell transplant in children with high-risk acute lymphoblastic leukaemia
a multi-site, non-randomised, phase I/II, paediatric trial with 2 arms. The Advanced Therapy Medicinal product (ATMP) tested in the study is donor-derived EBV-specific cytotoxic T-cells (EBV-CTL) tran [...]
Area: Advanced therapies
Phase: Phase I/II
Status: Archived
COBALT
Evaluation of CAR19 T-cells as an optimal bridge to allogeneic transplantation.
Single centre, single arm dose-escalation phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in adults with resistant or relapsed DLBCL. The ATIMP tested in this s [...]
Area: Advanced therapies
Phase: Phase I
Status: Closed
ICAT
Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after unrelated donor stem cell transplant.
ICAT is a multi-centre randomised phase II trial in adult patients with an underlying haematological malignancy undergoing unrelated donor peripheral blood stem cell transplant with Alemtuzumab-based [...]
Area: Advanced therapies
Phase: Phase II
Status: Closed
ITREC
Immunotherapy with Tacrolimus Resistant EBV CTL for Lymphoproliferative Disease after Solid Organ Transplant
ITREC is a multi-site, non-randomised phase I trial in children and adults with Post Transplant Lymphoproliferative Disease (PTLD) after solid organ transplant. The Advanced Therapy Investigational Me [...]
Area: Advanced therapies
Phase: Phase I
Status: Active (recruiting)
MAGNETO
Multi-modular Chimeric Antigen Receptor targeting GD2 in Neuroblastoma
A single-centre, non-randomised, open label Phase I clinical trial of an Advanced Therapy Investigational Medicinal Product (ATIMP) in children and teenagers aged 1-16 years with relapsed or refractor [...]
Area: Advanced therapies
Phase: Phase I
Status: Active (recruiting)
MCARTY
An open label, Phase 1 study evaluating the activity of Modular CAR T for myeloma
Phase1 rolling 6 trial design evaluating safety of a novel BCMA CAR alone (D8 CAR Tcells) and of CAR T cells co-expressing BCMA CAR and a CD19 CAR (D8/CAT CAR Tcells) in patients with relapsed/ refrac [...]
Area: Advanced therapies
Phase: Phase I
Status: Active (recruiting)
TACTICAL
Targeted stromal cells expressing TRAIL as a therapy for lung cancer
Phase I:Single site dose de-escalation design with a modified Bayesian continual reassessment method (mCRM) to estimate the recommended Phase II dose (RP2D) of MSCTRAIL in combination with pemetrexed/ [...]
Area: Advanced therapies
Phase: Phase I/II
Status: Active (recruiting)
Contact Us
Cancer Research UK & UCL Cancer Trials Centre
University College London
90 Tottenham Court Road
London
W1T 4TJ

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Email:
ctc.enquiries@ucl.ac.uk
Telephone:
+44 (0)20 7679 9898 (General CTC Enquiries)
Fax:
020 7679 9899
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