Trials portfolio
Addition of stereotactic body radiotherapy to systemic chemotherapy in locally advanced biliary tract cancers
ABC-07 is a multicentre phase II trial, with a 2:1 randomisation between 6 cycles of cisplatin and gemcitabine (CisGem) chemotherapy followed by Stereotactic Body Radiotherapy (SBRT), and 8 cycles Cis [...]
Area: Upper gastro-intestinal cancer
Phase: Phase II
Status: In follow-up (non-recruiting)
ABC-10 (SAFIR ABC-10 Precision Medicine)
SAFIR ABC-10 Precision Medicine - Molecular targeted maintenance therapy versus standard of care in advanced biliary cancer: an international, randomised, controlled, open- label, platform phase 3 trial
This is a Phase 3, multicentre, randomised, open-label trial to evaluate whether the introduction of molecular targeted therapy (MTT) as maintenance after 4 cycles of standard-of-care first-line syste [...]
Area: Upper gastro-intestinal cancer
Phase: Phase III
Status: In set-up (funded)
Biliary Tract Cancer Virtual Tissue Bank
A series of advanced biliary tract cancer (ABC) trials plan to investigate the value of interventions in addition to CisGem. This portfolio of trials include ABC-02,ABC-03, ABC-06, ABC-07, ACTICCA-1, [...]
Area: Upper gastro-intestinal cancer
Phase: Tissue collection
Status: In follow-up (non-recruiting)
Perioperative pembrolizumab and lenvatinib in Resectable Hepatocellular Carcinoma (HCC)
This is a randomised phase II study in patients withresectable hepatocellular carcinoma (HCC). Sixty patients from across the UK willbe randomised 1:1:1 and this trial is looking at giving pembrolizum [...]
Area: Upper gastro-intestinal cancer
Phase: Phase II
Status: Active (recruiting)
A pilot, open label, single-arm, phase 0, window of opportunity study of vandetanib-eluting radiopaque embolic beads (BTG-002814) in patients with resectable liver malignancies
VEROnA is a pilot, open label, single arm, Phase 0 window of opportunity study of vandetanib eluting radiopaque embolic beads.
Area: Upper gastro-intestinal cancer
Phase: Phase 0
Status: Closed
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