Report on underrepresentation of Black and minority ethnic communities in clinical trials published

In 2022, the Cancer Research UK & UCL Cancer Trials Centre (CTC) and B’Me Against Cancer (now The Rose Thompson Foundation) commissioned Dr [...]

(Publication) Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carboplatin, based on changes in CA125, in patients with relapsed platinum-sensitive high-grade serous or high-grade endometrioid ovarian cancer

Mukherjee UA, Hockings H, Counsell N, Patel A, Narayanan P, Wilkinson K, Dhanda H, Robinson K, McNeish I, Anderson ARA, Miller R, Gourley C, [...]

'Bridging the Gap': CTC organises collaborative event to raise awareness of clinical trials

Esther Arthur-Darkwa, trial manager at the Cancer Trials Centre, reports back from this weekend's event in Nottingham: In 2022 the UCL CTC e [...]

Results of cervical cancer trial hailed as 'biggest breakthrough for decades'

Findings from a CTC-led study into cervical cancer treatment have been published in the Lancet today, prompting further coverage for a trial [...]

Launch of the international SAFIR ABC10 program for patients with biliary tract cancer

Unicancer, University College of London (UCL) and the Belgian Group of Digestive Oncology (BGDO) announce the launch of the flagship SAFIR A [...]

Gynaecological Cancer Awareness Month in the UK

September marks Gynaecological Cancer Awareness Month in the UK, an annual campaign established by the Foundation for Women's Cancer (FWC) i [...]

(Publication) PembroWM: A phase II trial to investigate the safety and efficacy of rituximab and pembrolizumab in relapsed/refractory Waldenström's Macroglobulinaemia.

Kothari J, Eyre T, Rismani A, Ediriwickrema K, Edwards D, Galani S, Wilson W, Lawrie A, Clifton-Hadley L, McCarthy H, Collins A, Lewis D, Ar [...]

(Publication) Novel prognostic scoring systems for severe CRS and ICANS after anti-CD19 CAR T cells in large B-cell lymphoma

Sesques P, Kirkwood AA, Kwon M, Rejeski K, Jain MD, Di Blasi R, Brisou G, Gros FX, le Bras F, Bories P, Choquet S, Rubio MT, Iacoboni G, O'R [...]

(Publication) A Prospective Observational Cohort Study for Newly Diagnosed Osteosarcoma Patients in the UK: ICONIC Study Initial Results

Alexa Childs, Craig Gerrand, Bernadette Brennan, Robin Young, Kenneth S. Rankin, Michael Parry, Jonathan Stevenson, Adrienne M. Flanagan, Ra [...]

(Publication) The IMRiS Trial: A Phase 2 Study of Intensity Modulated Radiation Therapy in Extremity Soft Tissue Sarcoma

Beatrice Seddon MD, PhD, Franel Le Grange MD, Rita Simões MSc, Chris Stacey BSc, MSc, Shumona Shelly BSc, MSc, Sharon Forsyth BSc, Laura Whi [...]

(Publication) Results from UKALL60+, a phase 2 study in older patients with untreated acute lymphoblastic leukemia.

Patel B, Kirkwood AA, Rowntree CJ, Alapi KZ, Barretta E, Clifton-Hadley L, Creasey T, Lee S, Marks DI, Moorman AV, Morley N, Patrick P, Rana [...]

(Publication) Healthy tissue metabolism assessed by [18F]FDG PET/CT as a marker of prognosis and adverse events in advanced Hodgkin lymphoma patients.

Malaih AA, Kirkwood AA, Johnson P, Radhakrishnan V, Fischer BM, Barrington SF.

Trials community celebrates International Clinical Trials Day

Today marks International Clinical Trials Day, a global ACRP initiative intended to educate and inform the wider public about work being don [...]

Colorectal cancer trial quickly reaches recruitment target

A phase II colorectal cancer trial for patients coordinated by UCL CTC has met its recruitment target within 16 months of opening. The NEOad [...]

UCL marks World Cancer Day, CTC work highlighted

This Sunday will see World Cancer Day, an annual initiative which takes place every 4 February to raise awareness of cancer, and in turn hel [...]

MCARTY presented at ASH conference in California

A CTC study of CAR T cell therapy for patients with multiple myeloma presented its findings at a conference in the United States last week.M [...]

Lung Cancer Awareness Month

November marks Lung Cancer Awareness Month, an annual initiative aimed at raising public awareness of the third most common type of cancer i [...]

CTC study findings hailed as 'biggest cervical cancer breakthrough in 20 years'

Trial results presented by researchers from UCL and UCLH have shown a course of treatment with existing drugs prior to chemoradiation led to [...]

Findings published for CTC-coordinated study of CAR T-cell therapy

Today (30 August) will see a CTC-coordinated study publish some of its findings in the journal Blood1.The CARPALL study, whose Cohort 3 elem [...]

Immunotherapy treatment offers hope for men with hard-to-treat prostate cancer

Research coordinated by the CR UK & UCL CTC is showing promising signs for men with a certain type of prostate cancer. Prostate cancer remai [...]

Patient Engagement Day takes place for Cancer Trials Centre

Last Friday (23 June) saw the CR UK & UCL Cancer Trials Centre (CTC) host its first Patient Engagement Day, an event aimed at bringing toget [...]

UCL clinician scientist honoured with lifetime achievement award

Internationally recognised oncologist Professor Siow Ming Lee has been presented with the British Thoracic Oncology Group (BTOG) Lifetime Ac [...]

CARPALL update presented at 2023 EBMT conference in Paris

The CTC's CARPALL team report back from the 2023 EBMT conference in Paris, which saw the presentation of a data update on the CAR T-cell the [...]

Research autopsies reveal how incurable skin cancer resists treatment

Analysis of data from the CTC-coordinated PEACE study has revealed how some skin cancers stop responding to treatment. An in-depth analysis [...]

UCL community marks World Cancer Day, CTC patient stories highlighted

Tomorrow will see World Cancer Day, an annual initiative which takes place every 4 February to raise awareness of cancer, and in turn help t [...]

CTC staff members attend inaugural Black in Cancer conference

The first edition of the Cancer Research UK-supported Black in Cancer conference took place in London this week, with CR UK & UCL Cancer Tri [...]

CTC studies drive breakthrough in linking air pollution and cancer

Samples taken in the CTC studies PEACE and TRACERx have enabled researchers to uncover more about the link between air pollution and develop [...]

CTC gynae trial presents preliminary results

Results from a CTC gynae trial were presented to the European Society for Medical Oncology in Paris on Saturday. The PEACOCC trial, which op [...]

Bile duct cancer trial reaches recruitment target

This month saw the recruitment target met in a CTC trial for patients diagnosed with a hard-to-detect cancer affecting the bile duct. 83 pat [...]

CTC liver cancer study now open to recruitment in the UK

A study in the treatment of liver cancer run by the CR UK & UCL Cancer Trials Centre opened to recruitment at The Royal Free Hospital this m [...]

CTC study CARPALL presented at 2022 EHA conference

A CTC study of treatment for children and young adults with blood cancer was presented at a European Haematology Association conference in V [...]

Launch of NIHR-funded national trial for leukaemia

The CTC’s CiproPAL team provides an overview of the leukaemia study, which opened to recruitment at the end of June:A new nationwide trial h [...]

CTC studies to be exhibited at London’s Science Museum

An exhibition featuring the CTC-coordinated studies TRACERx and PEACE opens at the Science Museum in London today. Titled ‘Cancer Revolution [...]

PeRSEVERE project looks at withdrawal of consent in clinical studies

PRincipleS for handling end-of-participation EVEnts in clinical trials REsearch (PeRSEVERE) The UKCRC Registered CTU Network’s PeRSEVERE pro [...]

Clinical study to investigate new personalised treatment for ovarian cancer

Dr Michelle Lockley from Barts Cancer Institute at Queen Mary University of London has received funding from Barts Charity (approximately £5 [...]

CTC bladder cancer trial recruits first patient

This month has seen an initial patient recruited to the DURANCE trial — the first study of bladder cancer treatment coordinated by the CTC i [...]

Analysis published for CTC brain cancer study

The findings of a CTC-coordinated brain cancer study have been published in the oncology journal Cancers. The GALA-5 team have provided the [...]

Launch of NIHR-funded national trial for thyroid cancer

A new nationwide trial has launched in the UK for patients with low-risk thyroid cancer. The study aims to compare recurrence rates among pa [...]

Blood Cancer Awareness Month

September will see a number of events taking place in aid of Blood Cancer Awareness month. Every year, around 34,000 people in the UK are di [...]

CTC Office Refurbishment

The CTC offices will be closed for refurbishment from Friday 11th June - Sunday 29th August 2021 inclusive.Access to trial TMFs and patient [...]

Combination immunotherapy for metastatic prostate cancer shows promise

A combination of two antibody therapeutics - nivolumab and ipilimumab - has achieved the best response yet seen in the treatment of metastat [...]

Easter closure dates

The CTC will be closed from Thursday 2nd - Friday 9th April 2021 inclusive*. During the closure period there will be limited staff cover in [...]

CTC study in lung cancer screening breakthrough

The major London lung cancer screening study SUMMIT has announced findings with potentially huge implications for the treatment of lung canc [...]

Promising results for innovative radiotherapy treatment as CTC study gets virtual presentations

When the 25th annual CTOS (Connective Tissue Oncology Society) meeting took place virtually at the end of last year (18-21 November), attend [...]

ALLCAR19 update presented at the 62nd American Society of Hematology (ASH) meeting

The 62nd ASH annual conference, originally scheduled to be held in San Diego, California, took place during December 5 – 8 as an ‘all-virtua [...]

HCQ trial sees final analysis published

The HCQ trial, a trial run by the CR UK & UCL Cancer Trials Centre, was a randomised phase 2 trial investigating the additional benefit of h [...]

SUMMIT up and running once more

As the clinical trials community continues to adapt to the difficulties posed by the COVID-19 pandemic, some studies face unique challenges. [...]

INCA trial presented at 25th European Hematology Association Conference

The 25th EHA conference took place as a virtual exhibit last month (11th-21st June), with the CTC's INCA trial one of the studies receiving [...]

ACT II trial sees further analysis published

The CTC-led ACT II trial, a large randomised anal cancer study which took place in the UK between 2001-2008, has this month seen further ad- [...]

International Clinical Trials Day 2020 takes place in extraordinary circumstances

The clinical trials community finds itself at the forefront of the global news cycle as the 2020 edition of International Clinical Trials Da [...]

RAINBOW study open to recruitment

A randomised phase II/III study in Waldenströms macroglobulinaemia (WM) has opened to recruitment in the UK. The RAINBOW study is run by the [...]

Ovarian cancer study recruits 200th patient

This year has seen ovarian cancer study ICON9 register its 200th patient, with now over 100 patients randomised to receive study medication. [...]

World Cancer Day 2020

4 February marks World Cancer Day, a global initiative aimed at raising awareness of cancer and cancer treatment. The CR UK & UCL Cancer Tri [...]

CTC trials at the 18th British Thoracic Oncology Group (BTOG) conference 2020

The British Thoracic Oncology Group (BTOG) conference took place in Dublin this month, with a number of studies coordinated by the CR UK & U [...]

Recruitment underway for ovarian cancer study

The first two patients have been registered to a recently opened gynaecological cancer trial run by the CR UK & UCL Cancer Trials Centre. PR [...]

CTC trials at the 61st American Society of Hematology meeting

The American Society of Hematology meeting took place in Orlando this month, with excellent representation from studies coordinated by the C [...]

ICONIC trial up and running

An observational study in osteosarcoma has opened to recruitment in the UK. The ICONIC study is run by the CR UK & UCL Cancer Trials Centre. [...]

East London resident benefits from SUMMIT's early lung cancer screening

In August 2019, 77-year-old Bridget Barker from Hackney, east London, had successful robotic surgery at St Bartholomew’s Hospital to treat l [...]

POPPY trial opens to recruitment

A study investigating the treatment of advanced head and neck cancer, run by the CR UK & UCL Cancer Trials Centre, has opened to recruitment [...]

AVENuE Trial open to recruitment

A new trial for patients with newly diagnosed Hodgkin lymphoma opened to recruitment in September at the Churchill Hospital in Oxford. The t [...]

CTC study shows MRI as potential way forward for lung cancer scans

A CTC-coordinated lung cancer study published in The Lancet Respiratory Medicine has shown the benefits of using MRI scans in managing a pat [...]

PembroWM now open to recruitment

A new trial for patients with Waldenström’s macroglobulinaemia (PembroWM) opened to recruitment in September at the following hospitals: Der [...]

PARADIGM opens to recruitment

A new observational study in prostate cancer run by the CR UK & UCL Cancer Trials Centre opened at UCLH this month. PARADIGM will recruit pa [...]