The CTC offices are currently closed for refurbishment. Access to trial TMFs and patient records will be limited during this period. We will still be able to receive post during this time, but there may be a small delay in responding to this. Our fax lines may also be subject to disruption. Where possible, please direct all correspondence via email to trial-specific email addresses. We appreciate your patience and understanding.

Due to COVID-19 and current government guidance, UCL CTC staff continue to work remotely with limited access to the office. Please continue to email the trial specific mailbox with any urgent queries. For paper CRF trials, please continue to copy and scan CRFs to the trial inboxes (remove all patient identifiers except Trial Number and Initials) until further notice.

PARADIGM opens to recruitment
30 September 2019
A new observational study in prostate cancer run by the CR UK & UCL Cancer Trials Centre opened at UCLH this month.
PARADIGM will recruit patients with newly diagnosed metastatic prostate cancer across 12 centres in the UK. The aim of the study is to see if detecting plasma tumour DNA (ptDNA) in a patient's blood sample after 2 cycles of standard treatment is associated with a worse clinical outcome. The study hopes to recruit 170 patients over an 18 month period. 
Chief investigator Gert Attard remarked: 'To continue building on the recent improvements in the treatment of prostate cancer patients who are starting androgen deprivation therapy, we need a test that tells us with accuracy and in real-time whether a cancer is growing or responding to treatment. Plasma DNA holds promise to do this and could lead to a paradigm shift in how we manage this disease. Our trial aims to show our plasma DNA test distinguishes men whose treatment is working from those who require a change.'

Recruitment will continue until March 2021. For more details, see the trial webpage.
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