Patient Inclusion Criteria
1. A confirmed diagnosis of Hodgkin Lymphoma
2. HLA-compatible sibling or unrelated donor (at least 9/10 match)
3. Two subgroups of patients will be included in the study:
a. Primary refractory HL achieving
b. HL in first relapse achieving
4. Age 11-65 years
5. WHO performance status grade 0-1
6. Written informed consent
7. No concurrent serious medical condition that would preclude an allograft
Patient Exclusion Criteria
1. Progressive disease
2. Complete response after 2 cycles of salvage chemotherapy
3. Previous HDT or allograft
4. Impaired renal function: creatinine clearance
5. Impaired hepatic function: serum bilirubin >1.5x upper limit of normal (ULN) or alkaline phosphatase >2x ULN
6. Inadequate cardiac function (LVEF
7. Symptomatic respiratory compromise
8. Pregnant or lactating women
9. Previous malignancy in the past 5 years, except non-melanoma skin tumours or stage 0 (in situ) cervical carcinoma
10. HIV positivity