No treatments are specified in ICONIC. Patients should be treated according to national guidelines including UK guidelines for the management of bone sarcomas and applicable current and future NICE guidance.
· New histological diagnosis of osteosarcoma or in the absence of osteoid seen on biopsy, pathology and imaging supportive of a diagnosis of osteosarcoma. (It is well recognised that some patients may present with features suggestive of osteosarcoma (under 40 years, radiological abnormality compatible) but in whom no osteoid is detected in needle biopsy. Although categorised as spindle cell tumour of bone,such patients are usually treated in an identical approach to osteosarcoma. A definite diagnosis of osteosarcoma is then often possible after surgery when the entire resection specimen is available.)
· Written informed consent of patient and/or parent/legal guardian
· Diagnosis more than three months prior to registration
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